Background: Cutaneous squamous cell carcinoma (SCC) is associated with underlying immunosuppression, so it\r\nmay be a prognostic marker in patients with subsequent cancer. We therefore conducted a nationwide\r\npopulation-based Danish cohort study to evaluate whether a history of cutaneuos SCC has prognostic impact in\r\npatients with one of the following index cancers: non-Hodgkin�s lymphoma (NHL), or cancer of the lung, colon,\r\nrectum, breast, or prostate.\r\nMethods: We used Danish medical databases, which cover the entire Danish population of 5.6 million inhabitants\r\nand linked them using the unique personal identification number assigned to all Danish residents. From 1982\r\nthrough 2003, we identified 745 index cancer patients with and 79,143 without previous cutaneous SCC. Using Cox\r\nproportional hazards regression, we calculated adjusted mortality rate ratios (MRRs) with 95% confidence intervals\r\n(CIs).\r\nResults: Overall, previous SCC was associated with an increased mortality of cancer (MRR 1.13, 95% CI: 1.04-1.23).\r\nWhen examining index cancers separately, increased MRRs were found for cancer of the lung (MRR 1.23, 95% CI:\r\n1.05-1.43), colon (MRR 1.13, 95% CI: 0.92-1.40), rectum (MRR 1.29, 95% CI: 1.00-1.67), breast (MRR 1.09, 95% CI: 0.82-\r\n1.43), and NHL (MRR 1.09, 95% CI: 0.81-1.47), but not for prostate cancer (MRR 0.99, 95% CI: 0.83-1.18).\r\nConclusions: Our results suggest that previous cutaneous SCC is associated with poor prognosis of some cancers.\r\nThis finding stresses the importance of adherence to the existing recommendations of screening, diagnosis, and\r\ntreatment of cancer in patients with a history of SCC.
Loading....